You can cancel an American Airlines flight and potentially get a refund if you meet the ticket’s terms. Refundable tickets allow for a direct refund, while non-refundable fares might qualify for travel credits. If the cancellation happens within 24 hours of booking, all tickets are eligible for a refund. Review your booking on the American Airlines website to check eligibility, and then submit your refund request. If needed, reach out to customer service for help.